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What is Allopurinol?
Product Description

Common use
Allopurinol is an arthrifuge which inhibits xanthine oxidase and prevents formation of uric acid, from xanthine and hypoxanthine. Reduces the concentration of uric acid and its salts in body fluids, promotes the dissolution of existing urate deposits and prevents their formation in tissues and kidneys. The medication is used to treat diseases accompanied by hyperuricemia: gout (primary and secondary), nephrolithiasis (forming of kidney stones from urates); hyperuricemia (abnormally high level of uric acid in blood, both primary and secondary), which results in diseases involving enhanced dissolution of nucleoproteins and elevated levels of uric acid in the blood, including at various forms of leukemias, and also for treatment of some other conditions.

Dosage and direction

The dose of 100-800 mg a day may be prescribed depending on the condition. Initial dose of 100 mg can be increased gradually. Patients with acute gout and tophi (uric acid crystals in the tissues mostly around joints) should be treated with 300-400 mg of Allopuionol daily. Doses over 300 mg should be divided in two or more intakes. Take medication with food to avoid irritation of the stomach. Do not take large doses of vitamin C. Drink plenty of water to avoid formation of kidney stones. Limit consummation of alcoholic beverages and purine-rich foods such as sweetbreads, sardines, anchovies, kidneys, liver, and lentils.


Allopurinol should be taken over a period of several months so your symptoms start to reduce. Regular intake is important even if no immediate effect is noticed. You may experience acute attacks of gout more often at the beginning of treatment with Allopurinol even after normal uric acid levels are reached. The attacks will become shorter and less acute as the therapy continues. At any sign of allergic reaction stop taking the medication and consult your doctor as development of serious skin disease, irreversible damage to the liver, or generalized inflammation of a blood or lymph vessel is possible in some individuals. Inform your doctor if you have diabetes or kidney dysfunction before taking Allopurinol as correction of your dose is needed.


Allopurinol cannot be used in patients with hypersensitivity to the medication, in individuals with a hepatic or renal disorders, primary hemochromatosis, asymptomatic hyperuricemia, acute gout, pregnancy, lactation. The medication cannot be prescribed to children under 14 years of age unless the patients are treated for leukemia, malignant tumors and enzymatic disorders. C care. Renal failure, heart failure, diabetes mellitus, hypertension.

Possible side effect

The most common adverse reactions are diarrhea, nausea, allergy (rash, itching), and drowsiness. Stop taking the medication at first signs of rash, painful or bloody urination, eye irritation, or facial swelling, because these can be signs of a severe allergic reaction requiring immediate treatment. In rare cases Allopurinol can cause damage to nerve, kidney, and bone marrow as well as be a reason to a serious and even fatal allergic liver toxicity. In patients with liver toxicity appetite loss and itching may witness about it. The risk increases in patients with kidney impairment.

Drug interaction

The dose of oral mercaptopurine (Purinethol) and azathioprine (Imuran) should be reduced as Allopurinol increases their blood levels. Risk of skin rash increases in patients taking Allopurinol with penicillins.

Missed dose

Take the missed dose as soon as you remember unless it is almost time of your next dose. If it is almost time of your next dose just skip it and return to your regular scheme. Do not exceed the recommended dose.


In case of suspected overdose seek for immediate medical attention. No specific information is available about Allopurinol overdose.


Store at room temperature, below 25 C (77 F) and out of reach and children and pets.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis.All specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Allopurinol is used to treat gout and certain types of kidney stones. It is also used to prevent increased uric acid levels in patients receiving cancer chemotherapy. These patients can have increased uric acid levels due to release of uric acid from the dying cancer cells. Allopurinol works by reducing the amount of uric acid made by the body. Increased uric acid levels can cause gout and kidney problems.

How to use Allopurinol
Take this medication by mouth, usually once daily or as directed by your doctor. Take this medication after a meal to reduce stomach upset. If your dose is more than 300 milligrams a day, you will need to take several smaller doses during the day to get this amount (ask your doctor for directions).

It is best to drink a full glass of water with each dose and at least 8 more glasses (8 ounces each) of fluid a day. If your doctor has directed you to drink less fluid for other medical reasons, consult your doctor for further instructions. Your doctor may also instruct you on how to decrease acid in your urine (e.g., avoiding large amounts of ascorbic acid/vitamin C).

Dosage is based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

For the treatment of gout, it may take up to several weeks for this medicine to have an effect. You may have more gout attacks for several months after starting this medicine while the body removes extra uric acid. Allopurinol is not a pain reliever. To relieve pain from gout, continue to take your prescribed medicines for gout attacks (e.g., colchicine, ibuprofen, indomethacin) as directed by your doctor.
Side Effects
Stomach upset, nausea, diarrhea, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these rare but very serious side effects occur: numbness/tingling of arms/legs, easy bleeding/bruising, signs of infection (e.g., fever, persistent sore throat), unusual tiredness, signs of kidney problems (such as change in the amount of urine, painful/bloody urination), yellowing eyes/skin, severe stomach/abdominal pain, persistent nausea/vomiting, dark urine, unusual weight loss, eye pain, vision changes.

This medication can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Get medical help right away if you develop any rash.
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